Mitosis: Riding the Protofilament Curl

Intermediate filament proteins in nonfilamentous structures: transient disintegration and inclusion of subunit proteins in granular aggregates.

The intermediate filament cytoskeleton of cultured bovine kidney epithelial cells and human HeLa cells changes dramatically during mitosis. The bundles of cytokeratin and vimentin filaments progressively unravel into protofilament-like threads of 2-4 nm diameter, and intermediate filament protein is included in numerous, variously sized (0.2-1.5 microns) spheroidal aggregates containing densely...

Curl Size and Pelt Color Determination of Zandi Lambs Using Image Processing and Artificial Neural Network

In this study, a method based on using image processing and artificial neural network is introduced to determine pelt color and curl size of newborn lambs in Zandi sheep. The data was collected from 300 newborn lambs reared in the Zandi sheep breeding centre of Khojir, Tehran. Primarily, curl size and pelt color of new born lambs was recorded by experienced appraisers, and at the same time, sev...

Leading The Ignorant: Can Ignorance Eliminate The Free Riding Problem?

Conformational Stability of Fibrillar Amyloid-Beta Oligomers via Protofilament Pair Formation – A Systematic Computational Study

Amyloid-[Formula: see text] (A[Formula: see text]) oligomers play a crucial role in Alzheimer's disease due to their neurotoxic aggregation properties. Fibrillar A[Formula: see text] oligomerization can lead to protofilaments and protofilament pairs via oligomer elongation and oligomer association, respectively. Small fibrillar oligomers adopt the protofilament topology, whereas fibrils contain...

Coordination of Information Sharing and Cooperative Advertising in a Decentralized Supply Chain with Competing Retailers Considering Free Riding Behavior

This paper studies a decentralized supply chain in which a manufacturer sells a common generic product through two traditional and online retailers under free riding market. We assume that the traditional retailer provides the value added services but the online retailer does not. Factors such as retail prices, local advertising of the retailers, global advertising of the manufacturer and servi...